The shape of the normal adult kidney is like a bean, retroperitoneally present between twelve thoracic and third lumbar vertebra. The generation of synthetic ASL data allows flexible choice of parameters and the generated data are well suited for evaluation of processing pipelines. Dice indices ranged 0.80–0.93, 0.78–0.89, and 0.64–0.84 for whole kidney, cortex, and medulla, respectively. Mean perfusion values for cortex and medulla were close to the assumed perfusion of 250 mL/100 g/min and 50 mL/100 g/min, respectively. After registration, line profiles were smoother and, on average, MSSIMs increased by 25%. Overall, the pipeline evaluation yielded good results. Segmentation masks obtained by semi-automated procedure of the processing pipeline were compared to the original XCAT organ masks using the Dice index. Perfusion values obtained from the pipeline were compared to the values assumed when generating the synthetic data. Registration performance was evaluated qualitatively with line profiles and quantitatively with mean structural similarity index measures (MSSIMs). Our in-house developed processing pipeline was then evaluated in terms of registration, quantification, and segmentation using the synthetic data. In this work, synthetic renal ASL data were generated using body models from the XCAT phantom and perfusion was added using the general kinetic model. To alleviate challenges arising solely from differences in processing pipelines, synthetic data are of great value. However, differences in acquisition (e.g., ASL parameters, readout) and processing (e.g., registration, segmentation) between studies impede the comparison of results. Arterial spin labeling (ASL), a completely non-invasive magnetic resonance imaging technique, is a promising method for this application. In conclusion, ¹³¹ -Hippuran labelled compound produced by CANST-BATAN Bandung is relatively stable up to 30 days and not affected by storage temperature.Īccurate quantification of perfusion is crucial for diagnosis and monitoring of kidney function. Furthermore, the result of One-way ANOVA test showed that there was no significant difference of radiochemical purity in various storage temperatures. Normality and homogeneity test showed the radiochemical purity is normally distributed and has homogenous variance at three different storage temperature. Statistical analysis using SPSS was performed to determine whether there was a significant difference in the radiochemical purity of each storage temperature. While on 30” day, radiochemical purity in storage temperatures of 4, 25, and 30☌ are 97.04, 96.37, and 96.96% respectively. The initial radiochemical purity is 99.52%. The static phase used was whatman 1 paper, while mobile phase was phosphate buffer pH 9. Radiochemical purity of each temperature determined by paper electrophoresis method on day 1, 6, 9, 13, 20, 23, and 30. Three storage temperatures were prepared as follows: 4, 25, and 30 th C. ¹³¹ -Hippuran stability testing needs to be done related to the decay of radioactive compounds. HPLC analysis were performed to specified which fraction has higher radiochemical purity and will be used for patients. ¹³¹ -Hippuran was purified by column chromatography method. PSTNT has succeeded produce ¹³¹ -Hippuran to cover the demand from An Nur Urology-Specialized Hospital, Yogyakarta. Radiation from the labelled compound tracked by gamma detector in Renograph. The labelled compound solution administered to patients via intravenous injection. I-ortho-iodo-hippuiic acid ( ¹³¹ -Hippuran) labelled compound has been used in nuclear medicine for renal function evaluation.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |